Industrial Refrigerants, mainly hydrofluorocarbons (HFCs), are an integral part of industrial society, being main chemical components for systems such air conditioning and food processing. The EU industrial refrigeration is a pivotal sector for the EU area, accounting for a market size near €5 bln with a growth rate expected at 6% between 2015 and 2020 and an overall workforce of highly skilled profiles of 1 mln. However, HFCs are considered harmful to the environment, being source of substantial GHG emissions (>50Mt CO2eq/year) and thus global warming. In most HFC-using sectors, alternatives like HFO’s , carbon dioxide , Ammonia, HC’s and/or blends thereof appear very appealing as they have lower global warming potential (GWP) than HFCs. Nevertheless the area of alternative and sustainable climate-friendly low GWP gases in the refrigeration sector remains largely unexplored and lacks of widely accepted alternatives. The LIFE-IREPRO pilot project intends to demonstrate the sustainability and efficiency of highly innovative batch process for the production of novel climate-friendly low-GWP gases constituted by hydrocarbons (i.e. selected mixtures of two or more components among Ethane Propane, Propylene, Butane, Isobutane, Butene/Isobutene and Dimethylether) for industrial refrigeration applications, and characterised by much lower Global Warming Potential (GWP) with respect to the state-of-the-art. The project will completely revolutionize the production process of industrial gases by rethinking the distillation step, by turning a traditional high-cost, inflexible production process to a flexible, secure, cost and energy efficient one, i.e. by introducing an innovative separation column and restructuring the blending system to achieve products with > 99% purity. The new process will overcome strong technological barriers that have hitherto limited the uptake of hydrocarbons climate-friendly alternatives, notably process cost and poor versatility, presence of unwanted by-products and safety treatment and manipulation of highly flammable gases. Importantly, the new process will bring as well to a consistent reduction of water (~100%) and energy consumption (~66%). Project outcomes will have important socio-economic, including health, and environmental impacts at the EU and global levels and at the same time, it may contribute to the update of future EU policies and legislation on Climate change Mitigation.